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Introduction Cysteine, a sulfhydryl-containing proteinogenic amino acid essential for the human body, is employed in a variety of metabolic pathways, such as the regulation of reduced glutathione (GSH), a major endogenous antioxidant molecule and the generation of sulfur-containing biomolecules such as hydrogen sulfide (H 2 S), taurine, coenzyme A and biotin ( Figure 1 ) ( Figure 1 Cysteine metabolism in cancer and tumor microenvironment It is increasingly noted that altered levels of amino acids including cysteine in the tumor microenvironment, by uptake or processing of both intracellular and extracellular regions, have emerged as potential markers of tumor progression

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This study was financially supported by the Hainan Provincial Natural Science Foundation of China (822QN463), Joint Program on Health Science and Technology Innovation of Hainan Province (WSJK2024QN013 and WSJK2025QN076), and Hainan Medical College 2024 Student Innovation and Entrepreneurship Training Program (X202411810135)

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